CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model
Freja K. Ekman, David S. Ojala, Maroof M. Adil, Paola Andrea Lopez Zapana, David V. Schaffer, Thomas Gaj
- ISSN / E-ISSN
- — / —
- DOI
- 10.1016/j.omtn.2019.07.009 ↗
- Volume · Issue · Pages
- 17 · — · 829-839
- Publisher
- Cell Press
- Article URL
- https://doi.org/10.1016/j.omtn.2019.07.009 ↗
- Article details
- Unverified
Publication date (each date has its type and source)
26 Jul 2019
OpenAlex publication date · source: OpenAlex
| Type | Date | Source |
|---|---|---|
| OpenAlex publication date | 26 Jul 2019 | OpenAlex |
Keywords (as given): Huntington's disease; CRISPR/Cas9 genome editing; huntingtin gene; CAG repeat expansion; R6/2 mouse model; SaCas9; adeno-associated virus vectors; in vivo gene therapy; striatum; neuronal inclusions; lifespan extension; motor impairment; neurodegenerative diseases
HEC Status at Publication Not the journal's current status
HEC Status at PublicationNot conclusive
Historical status could not be conclusively determined.
- HEC status cannot be determined for this date: no HEC list is recorded as in effect on it.
Best available information, not a definitive status: HEC status cannot be determined for this date: no HEC list is recorded as in effect on it.
- Journal
- Molecular Therapy - Nucleic Acids
- Publication date used
- 26 Jul 2019 (OpenAlex publication date)
- Applicable HEC period
- None recorded for this date
- Category
- —
- Recognition status
- Unknown (NO_PERIOD_FOR_DATE)
- Source
- —
- Verification status
- Not available
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