Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia‐Oliveira, Miguel Angel Prieto, Ka‐Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesús Simal‐Gándara, Wai San Cheang, Jianbo Xiao
ISSN / E-ISSN
— / —
DOI
10.1016/j.fshw.2023.03.021 ↗
Volume · Issue · Pages
12 · 6 · 1991-2000
Publisher
Elsevier BV
Article URL
https://doi.org/10.1016/j.fshw.2023.03.021 ↗
Article details
Unverified
Publication date (each date has its type and source)
05 Apr 2023
OpenAlex publication date · source: OpenAlex
Dates on record for this article
TypeDateSource
OpenAlex publication date05 Apr 2023 OpenAlex

Keywords (as given): apigenin; luteolin; baicalein; flavonoids; insulin resistance; PI3K/Akt signaling; GLUT4; GSK3β; glycogen synthesis; reactive oxygen species; advanced glycation end products; NF-κB; IRS-1; insulin receptor substrate 2; HepG2 cells; high glucose; dexamethasone; glucose uptake; anti-diabetic effects

HEC Status at Publication Not the journal's current status

HEC Status at PublicationConclusive
HEC status at publication Recognized X
Based on the recorded HEC dataset applicable to the article's publication date. Listed as X in the HEC list for 2022–23.
Journal
Food Science and Human Wellness
Publication date used
05 Apr 2023 (OpenAlex publication date)
Applicable HEC period
2022–23 (version 2) · 01 Jul 2022 – 30 Jun 2023
Category
X
Recognition status
Recognized (OK_RECORD_FOUND)
Source
hjrs-2022-23 row 5919
Verification status
Verified against source · last verified 16 Oct 2026
This is an automatically generated summary based on the information available on the publication date. Terms & conditions apply.